The trouble with sliding windows and the selective pressure in BRCA1.
Sliding-window analysis has widely been used to uncover synonymous (silent, d(S)) and nonsynonymous (replacement, d(N)) rate variation along the protein sequence and to detect regions of a protein under selective constraint (indicated by d(N)d(S)).The approach compares two or more protein-coding genes and plots estimates d(/)(S) and aftermath caber